
{"id":6942,"date":"2017-02-13T22:04:50","date_gmt":"2017-02-13T22:04:50","guid":{"rendered":"https:\/\/aspartame.kellendev.com\/gastrointestinal-issues-gut-microbiome\/"},"modified":"2018-11-05T18:30:44","modified_gmt":"2018-11-05T18:30:44","slug":"gastrointestinal-issues-gut-microbiome","status":"publish","type":"post","link":"https:\/\/global.aspartame.org\/ja\/gastrointestinal-issues-gut-microbiome\/","title":{"rendered":"\u6d88\u5316\u5668\u7cfb\u306e\u554f\u984c\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9"},"content":{"rendered":"<p><strong>By the <a href=\"http:\/\/caloriecontrol.org\/about\/\" target=\"_blank\" rel=\"noopener\">Calorie Control Council<\/a><\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-7095 alignright\" src=\"\/wp-content\/uploads\/2017\/02\/AdobeStock_120047147-150x150.jpeg\" alt=\"\" width=\"220\" height=\"220\" \/><\/p>\n<p>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u3068\u6d88\u5316\u5668\u7cfb\u75c7\u72b6\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306e\u6b86\u3069\u306e\u7591\u554f\u306f\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u5f8c\u306e\u6d88\u5316\u5668\u7cfb\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3067\u89e3\u660e\u3067\u304d\u307e\u3059\u3002\u30ad\u30fc\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u79c1\u305f\u3061\u304c\u6bce\u65e5\u4f55\u7a2e\u985e\u3082\u98df\u3079\u3066\u3044\u308b\u98df\u54c1\u3068\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3082\u30d2\u30c8\u306e\u4f53\u5185\u3067\u306f\u540c\u3058\u7d4c\u8def\u3092\u305f\u3069\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><strong>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306e\u6d88\u5316<\/strong><\/p>\n<p>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306f\u30a2\u30df\u30ce\u9178\u3067\u3042\u308b\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3068\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5375\u3001\u725b\u4e73\u3001\u5927\u8c46\u306a\u3069\u306b\u542b\u307e\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5206\u89e3\u3059\u308b\u306e\u3068\u540c\u3058\u6d88\u5316\u9175\u7d20\u306b\u3088\u3063\u3066\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3082\u5c0f\u8178\u5185\u3067\u5b8c\u5168\u306b\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3092\u6d88\u5316\u5206\u89e3\u3059\u308b\u3068\u30e1\u30bf\u30ce\u30fc\u30eb\u3082\u7523\u751f\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u3082\u3001\u4ed6\u306e\u98df\u54c1\u306e\u6d88\u5316\u6642\u306b\u7523\u751f\u3055\u308c\u308b\u30e1\u30bf\u30ce\u30fc\u30eb\u3068\u540c\u3058\u3067\u3059\u3002\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u304c\u6d88\u5316\u3055\u308c\u308b\u3053\u3068\u3067\u7523\u751f\u3059\u308b\uff13\u6210\u5206\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3001\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u3001\u30e1\u30bf\u30ce\u30fc\u30eb\u306f\u3001\u4ed6\u306e\u98df\u4e8b\u7531\u6765\u3067\u3082\u751f\u6210\u3057\u3001\u4f53\u5185\u3067\u540c\u3058\u3088\u3046\u306b\u5438\u53ce\u3055\u308c\u3001\u540c\u3058\u3088\u3046\u306b\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u4f53\u5185\u3067\u306f\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306f\u901f\u3084\u304b\u306b\u6d88\u5316\u3055\u308c\u308b\u305f\u3081\u3001\u8840\u6db2\u4e2d\u306b\u76f4\u63a5\u5165\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p><strong>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306b\u3088\u308b\u6d88\u5316\u5668\u7cfb\u306e\u554f\u984c\u306b\u79d1\u5b66\u7684\u6839\u62e0\u306a\u3057<\/strong><\/p>\n<p>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u5165\u308a\u98f2\u98df\u54c1\u306e\u6442\u53d6\u5f8c\u306b\u6d88\u5316\u5668\u7cfb\u969c\u5bb3\u3092\u767a\u75c7\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u3068\u3057\u3066\u306f\u3001\u8edf\u4fbf\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u3001\u6392\u4fbf\u983b\u5ea6\u306e\u4f4e\u4e0b\u3001\u5410\u304d\u6c17\u3001\u80c3\u3051\u3044\u308c\u3093\u3001\u81a8\u6e80\u611f\u3001\u80c3\u8178\u708e\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u75c7\u72b6\u306f\u3001\u4ed6\u306e\u98f2\u98df\u54c1\u306e\u591a\u304f\u3067\u3082\u6442\u53d6\u5f8c\u306b\u3088\u304f\u307f\u3089\u308c\u308b\u969c\u5bb3\u3067\u3042\u308a\u3001\u5185\u670d\u85ac\u306e\u6295\u4e0e\u3001\u75c5\u6c17\u3001\u5fc3\u7406\u7684\u30fb\u611f\u60c5\u7684\u306a\u554f\u984c\u306b\u3088\u3063\u3066\u3082\u3082\u305f\u3089\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<div class=\"su-pullquote su-pullquote-align-right\"><strong>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306b\u95a2\u9023\u3059\u308b\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u305f\u6d88\u5316\u5668\u7cfb\u75c7\u72b6\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u6295\u4e0e\u91cf\u306e\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3068\u30d7\u30e9\u30bb\u30dc\u3068\u3092\u305d\u308c\u305e\u308c\u540c\u4e00\u5f62\u72b6\u306e\u30ab\u30d7\u30bb\u30eb\u306b\u5165\u308c\u3066\u3001\u6700\u95776<\/strong><strong>\u30f5\u6708\u9593\u306b\u308f\u305f\u3063\u3066\u691c\u8a0e\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/strong>\uff08Nehrling\u3089\u3001Leon\u3089)<\/div>\n<p>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306b\u95a2\u9023\u3059\u308b\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u305f\u6d88\u5316\u5668\u7cfb\u75c7\u72b6\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u6295\u4e0e\u91cf\u306e\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3068\u30d7\u30e9\u30bb\u30dc\u3068\u3092\u305d\u308c\u305e\u308c\u540c\u4e00\u5f62\u72b6\u306e\u30ab\u30d7\u30bb\u30eb\u306b\u5165\u308c\u3066\u3001\u6700\u95776\u30f5\u6708\u9593\u306b\u308f\u305f\u3063\u3066\u691c\u8a0e\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u78ba\u8a8d\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\uff08Nehrling\u3089\u3001Leon\u3089\uff09<\/p>\n<p>\u6d88\u5316\u5668\u7cfb\u969c\u5bb3\u306f\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u3044\u305a\u308c\u306b\u3082\u8a8d\u3081\u3089\u308c\u3001\u3059\u3079\u3066\u8efd\u5ea6\uff5e\u4e2d\u5ea6\u3067\u3042\u308a\u3001\u767a\u75c7\u3057\u305f\u88ab\u9a13\u8005\u6570\u3067\u3082\u3001\u88ab\u9a13\u80051\u4eba\u3042\u305f\u308a\u304c\u767a\u73fe\u3057\u305f\u75c7\u72b6\u6570\u306b\u304a\u3044\u3066\u3082\u30012\u7fa4\u9593\u306b\u7d71\u8a08\u5b66\u7684\u306a\u6709\u610f\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u304c\u3001\u30bb\u30ea\u30a2\u30c3\u30af\u75c5\u3001\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u3001\u71b1\u5e2f\u6027\u30b9\u30d7\u30eb\u30fc\u306a\u3069\u306e\u6d88\u5316\u5668\u7cfb\u75be\u60a3\u60a3\u8005\u306b\u5f71\u97ff\u3059\u308b\u304b\u3069\u3046\u304b\u3068\u3044\u3046\u7591\u554f\u3082\u6295\u3052\u639b\u3051\u3089\u308c\u307e\u3057\u305f\u30022007\u5e74\u306e<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17828671\">Magnuson\u4ed6<\/a>\u306b\u3088\u308b\u691c\u8a0e\u3067\u306f\u3001\u6d88\u5316\u5668\u7cfb\u75be\u60a3\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3057\u305f\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u5f8c\u306e\u8840\u6f3f\u4e2d\u30a2\u30df\u30ce\u9178\u6fc3\u5ea6\u3092\u8a55\u4fa1\u3057\u305f\u5b66\u8853\u6587\u732e\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u5225\u306e\u6587\u732e\u3067\u306f\u3001\u6d88\u5316\u5668\u7cfb\u75be\u60a3\u60a3\u8005\u306b\u30a2\u30df\u30ce\u9178\u3084\u30da\u30d7\u30c1\u30c9\u306e\u5438\u53ce\u969c\u5bb3\u304c\u307f\u3089\u308c\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001\u6d88\u5316\u5668\u7cfb\u75be\u60a3\u60a3\u8005\u306b\u3088\u308b\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u5f8c\u306e\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u3068\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u306e\u8840\u6f3f\u30a2\u30df\u30ce\u9178\u6fc3\u5ea6\u306f\u3001\u5065\u5eb7\u306a\u4eba\u306b\u307f\u3089\u308c\u308b\u6fc3\u5ea6\u3068\u6bd4\u8f03\u3057\u3066\u540c\u7b49\u307e\u305f\u306f\u4f4e\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u89b3\u70b9\u304b\u3089<\/strong><\/p>\n<p>\u79c1\u305f\u3061\u306e\u6d88\u5316\u5668\u5b98\u3001\u7279\u306b\u8178\u306b\u306f\u6570\u5343\u7a2e\u985e\u306e\u5fae\u751f\u7269\u304c\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u5fae\u751f\u7269\u3092\u7dcf\u79f0\u3057\u3066\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3068\u3044\u3044\u307e\u3059\u3002\u8fd1\u5e74\u3067\u306f\u3001\u5065\u5eb7\u3084\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u8178\u5185\u5fae\u751f\u7269\u306e\u5f79\u5272\u3092\u691c\u8a0e\u3059\u308b\u7814\u7a76\u304c\u4e16\u754c\u4e2d\u3067\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u306e\u591a\u304f\u306f\u3001\u80a5\u6e80\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u5168\u8eab\u6027\u708e\u75c7\u3001\u81ea\u9589\u75c7\u3001\u591a\u767a\u6027\u786c\u5316\u75c7\u3001\u81ea\u5df1\u514d\u75ab\u6027\u75be\u60a3\u306a\u3069\u306b\u7740\u76ee\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21633075\">Shanahan-Murphy<\/a>\u3001<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21543530\">Jumpertz\u4ed6<\/a>\u3001<a href=\"https:\/\/www.omicsonline.org\/bacteria-and-obesity-the-proportion-2161-1076-3-152.pdf\">Kotzampassi\u4ed6<\/a>\uff09\u3002\u6700\u65b0\u306e<a href=\"https:\/\/www.omicsonline.org\/bacteria-and-obesity-the-proportion-2161-1076-3-152.pdf\">\u7814\u7a76<\/a>\u3067\u306f\u3001\u79c1\u305f\u3061\u306e\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306f\u4eba\u305d\u308c\u305e\u308c\u306b\u56fa\u6709\u306e\u3082\u306e\u3067\u3001100\u5146\u500b\u3082\u306e\u7d30\u83cc\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3089\u306e\u7d30\u83cc\u306e\u3046\u3061\u7a2e\u985e\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u306e\u306f50\u9580\u307b\u3069\u306b\u904e\u304e\u305a\u3001\u30d5\u30a1\u30fc\u30df\u30af\u30c6\u30b9\u9580\u3068\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u9580\u304c\u30d2\u30c8\u306e\u8178\u5185\u7d30\u83cc\u306e90\uff05\u4ee5\u4e0a\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u3002\uff08\u8a33\u6ce8\uff1a\u751f\u7269\u5b66\u306e\u5206\u985e\u65b9\u6cd5\u3067\u3001\u5927\u304d\u306a\u307b\u3046\u304b\u3089\u300c\u9580\u30fb\u7db1\u30fb\u76ee\u30fb\u79d1\u30fb\u5c5e\u30fb\u7a2e\u300d\u3068\u306a\u308b\uff09\u3053\u308c\u307e\u3067\u306b\u5f97\u3089\u308c\u3066\u3044\u308b\u7814\u7a76\u7d50\u679c\u304b\u3089\u306f\u3001\u30d5\u30a1\u30fc\u30df\u30af\u30c6\u30b9\u9580\u306b\u5bfe\u3057\u3066\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u9580\u306e\u6bd4\u7387\u304c\u4f4e\u3044\u4eba\u306e\u65b9\u304c\u80a5\u6e80\u306b\u306a\u308a\u6613\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u30d0\u30af\u30c6\u30ed\u30a4\u30c7\u30b9\u9580\u306e\u65b9\u304c\u591a\u304f\u306e\u30ab\u30ed\u30ea\u30fc\u3092\u8178\u5185\u3067\u62bd\u51fa\u3067\u304d\u308b\u306e\u3067\u306f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f46\u3057\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u5909\u5316\u304c\u80a5\u6e80\u306e\u539f\u56e0\u306b\u306a\u308b\u306e\u304b\u3001\u80a5\u6e80\u306e\u7d50\u679c\u3068\u3057\u3066\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u5909\u5316\u3059\u308b\u306e\u304b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u4eca\u5f8c\u3001\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\uff08NIH\uff09\u306e\u5171\u901a\u57fa\u91d1\u306b\u3088\u308a\u904b\u55b6\u3055\u308c\u308b\u30d2\u30c8\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08HMP\uff09\u304c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u79c1\u305f\u3061\u306e\u5065\u5eb7\u3084\u75be\u60a3\u306b\u3069\u306e\u69d8\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u304b\u89e3\u304d\u660e\u304b\u3057\u3066\u3044\u304f\u3067\u3057\u3087\u3046\u3002\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3092\u610f\u56f3\u7684\u306b\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u63a8\u5968\u98df\u306b\u3064\u3044\u3066\u8ad6\u3058\u3089\u308c\u308b\u306e\u306f\u3001\u307e\u3060\u5148\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<p><strong>\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306b\u95a2\u3059\u308b\uff12\u3064\u306e\u7814\u7a76\u306b\u53cd\u3057\u3066\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306f\u5927\u8178\u306b\u5230\u9054\u3057\u306a\u3044<\/strong><\/p>\n<p>\u98df\u4e8b\u3001\u904b\u52d5\u3001\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\u306a\u3069\u306e\u5909\u5316\u3001\u80c3\u30d0\u30a4\u30d1\u30b9\u624b\u8853\u3001\u6297\u751f\u7269\u8cea\u30fb\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u30fb\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u306e\u4f7f\u7528\u306a\u3069\u306e\u7d50\u679c\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u7d44\u6210\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26474235\">\u5831\u544a<\/a>\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a href=\"http:\/\/www.nature.com\/articles\/ncomms4654\">Schnorr\u4ed6<\/a>\u306f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u6025\u901f\u306b\u5909\u5316\u3067\u304d\u308b\u306e\u306f\u3001\u98df\u7ce7\u4f9b\u7d66\u304c\u7d76\u3048\u305a\u5909\u5316\u3059\u308b\u72e9\u731f\u6c11\u65cf\u304c\u751f\u5b58\u305f\u3081\u306b\u5099\u3048\u305f\u9032\u5316\u7684\u306a\u7279\u6027\u3067\u3042\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u95a2\u3059\u308b2\u3064\u306e\u7814\u7a76\u306b\u8a71\u3092\u9032\u3081\u308b\u524d\u306b\u3001<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.2903\/j.efsa.2013.3496\/epdf\">\u6b27\u5dde\u98df\u54c1\u5b89\u5168\u6a5f\u95a2<\/a>(EFSA)\u304c\u767a\u8868\u3057\u305f\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u6700\u65b0\u306e\u8a55\u4fa1\uff082013\u5e74\uff09\u3067\u306f\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3082\u305d\u306e\u5206\u89e3\u7269\u3082\u5927\u8178\u306b\u306f\u5230\u9054\u3057\u306a\u3044\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u81ea\u4f53\u306f\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u3068\u306e\u3067\u3059\u3002Suez\u3089\u3068Palmnas\u3089\u306b\u3088\u308b\u7814\u7a76\u3067\u306f\u3001\u4f4e\u30ab\u30ed\u30ea\u30fc\u7518\u5473\u6599\uff08LCS\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u304c\u5909\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u305f\u4f4e\u30ab\u30ed\u30ea\u30fc\u7518\u5473\u6599\u306f\u3001\u73fe\u5728\u306e\u4e3b\u306a\u4f4e\u30ab\u30ed\u30ea\u30fc\u7518\u5473\u6599\u3068\u306f\u5927\u304d\u304f\u7570\u306a\u308b\u5316\u5b66\u7d44\u6210\u3067\u3042\u308b\u3053\u3068\u3001\u305d\u308c\u3089\u306e\u7269\u8cea\u3092\u6442\u53d6\u3057\u305f\u5834\u5408\u306e\u4ee3\u8b1d\u7d4c\u8def\u3082\u7570\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u73fe\u5728\u306e\u4f4e\u30ab\u30ed\u30ea\u30fc\u7518\u5473\u6599\u304c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306b\u5bfe\u3057\u3066\u540c\u69d8\u306e\u4f5c\u7528\u304c\u3042\u308b\u3068\u65ad\u5b9a\u3059\u308b\u3053\u3068\u306f\u51fa\u6765\u307e\u305b\u3093\u3002\u3053\u3046\u3057\u305f\u7814\u7a76\u304c\u767a\u8868\u3055\u308c\u305f\u6642\u306b\u306f\u3001\u5148\u305a\u300c\u3069\u306e\u4f4e\u30ab\u30ed\u30ea\u30fc\u7518\u5473\u6599\u3092\u4f7f\u7528\u3057\u305f\u306e\u304b\u300d\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305a\u3001\u3055\u307e\u3056\u307e\u306a\u5b9f\u65bd\u8a08\u753b\u3084\u5b9f\u9a13\u6761\u4ef6\u3067\u884c\u308f\u308c\u305f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25231862\">Suez\u4ed6<\/a>\u306b\u3088\u308b10\u306e\u7814\u7a76\u3092\u307f\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u30027\u4ef6\u304c\u30de\u30a6\u30b9\u30013\u4ef6\u304c\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u3059\u3002\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3068\u30b9\u30af\u30e9\u30ed\u30fc\u30b9\u304c\u7528\u3044\u3089\u308c\u305f\u306e\u306f\u3001\u305d\u306e\u3046\u3061\u306e1\u3064\u306e\u7814\u7a76\u306e\u307f\u3067\u3057\u305f\u3002\u3069\u3061\u3089\u304b\u306e\u7518\u5473\u6599\u304c\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u3084\u8840\u7cd6\u5024\u306b\u5f71\u97ff\u3059\u308b\u3068\u3044\u3046\u4e3b\u5f35\u3092\u652f\u6301\u3059\u308b\u30c7\u30fc\u30bf\u306f\u898b\u5f53\u305f\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u3069\u3053\u308d\u304b\u3001\u767a\u8868\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3067\u306f\u3001\u3053\u306e2\u7a2e\u985e\u306e\u4f4e\u30ab\u30ed\u30ea\u30fc\u7518\u5473\u6599\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u306e\u9593\u306b\u306f\u3001\u5dee\u7570\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306b\u5bfe\u3057\u3066\u306f\u3001\u7d50\u679c\u306e\u89e3\u91c8\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u7591\u554f\u304c\u8907\u6570\u898b\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u75c7\u4f8b\u6570\u304c\u5c11\u306a\u3044\u3053\u3068\u3001\u9078\u3093\u3060\u30b5\u30f3\u30d7\u30eb\u304c\u7fa4\u3092\u4ee3\u8868\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u3001\u5bfe\u7167\u7fa4\u3092\u304a\u3044\u3066\u3044\u306a\u3044\u3053\u3068\u3001\u57fa\u6e96\u3068\u306a\u308b\u30c7\u30fc\u30bf\u304c\u306a\u3044\u3053\u3068\u3001\u75c7\u72b6\u306e\u767a\u73fe\u306b\u5236\u9650\u304c\u3042\u308b\u3053\u3068\u3001\u8a18\u61b6\u30d0\u30a4\u30a2\u30b9\u304c\u3042\u308b\u3053\u3068\u306a\u3069\u3067\u3059\u3002\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3092\u9577\u671f\u4f7f\u7528\u3057\u3066\u3082\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u542b\u3081\u3066\u30d2\u30c8\u306e\u8840\u7cd6\u5024\u306b\u5f71\u97ff\u3057\u306a\u3044\u3068\u3044\u3046\u591a\u6570\u306e\u79d1\u5b66\u7684\u6839\u62e0\u306b\u77db\u76fe\u3057\u3066\u3044\u307e\u3059\u3002\uff08<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3902420\">Leon\u4ed6<\/a>\u3001<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3902420\">Nehrling\u4ed6<\/a>\u3001<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29659969\">Higgins\u4ed6<\/a>\uff09<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25313461\">Palmnas\u4ed6<\/a>\u306b\u3088\u308b\u7814\u7a76\u306f\u3001\u5c11\u91cf\u306e\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u3092\u9577\u671f\u9593\u7d99\u7d9a\u3057\u305f\u5834\u5408\u3001\u4ee3\u8b1d\u3084\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u5909\u5316\u3068\u95a2\u4fc2\u304c\u3042\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b\u76ee\u7684\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u98df\u990c\u3067\u80a5\u6e80\u3092\u8a98\u767a\u3055\u305b\u305fSD\u7cfb\u30e9\u30c3\u30c844\u5339\u3092\u3001\u6a19\u6e96\u56fa\u5f62\u98fc\u6599\u307e\u305f\u306f\u9ad8\u8102\u80aa\u56fa\u5f62\u98fc\u6599\u306e\u4e8c\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u30662\u9031\u9593\u3001\u6b21\u306b\u6c34\u307e\u305f\u306f\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u3067\u7518\u304f\u3057\u305f\u6c34\u306e2\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3066\u3055\u3089\u306b8\u9031\u9593\u7d99\u7d9a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u8a66\u9a13\u3067\u306f\u51e6\u7f6e\u7fa4\u304c4\u7a2e\u985e\u306b\u306a\u308b\u306f\u305a\u3067\u3059\u304c\u3001\u7814\u7a76\u7d50\u679c\u3067\u306f\u3001\u305d\u306e\u3046\u30612\u7fa4\u306e\u30c7\u30fc\u30bf\u306f\u904e\u53bb\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u306e\u5bfe\u7167\u7fa4\u306e\u4e00\u90e8\u3068\u3057\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u30018\u9031\u6642\u306b\u7cd6\u8ca0\u8377\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u300110\u9031\u6642\u306b\u4f53\u91cd\u6e2c\u5b9a\u3001\u7cde\u4fbf\u63a1\u53d6\u3001\u8840\u6db2\u63a1\u53d6\u3092\u3057\u305f\u3068\u3044\u3046\u8a18\u8f09\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u57fa\u6e96\u70b9\u3068\u3057\u3066\u7528\u3044\u308b\u8a66\u9a13\u51e6\u7f6e\u524d\u30c7\u30fc\u30bf\u306f\u6e2c\u5b9a\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u7814\u7a76\u306b\u304a\u3051\u308b\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u7fa4\u306e\u7d50\u679c\u3067\u306f\u3001\u6b63\u5473\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u91cf\u306e\u4f4e\u4e0b\u3001\u4f53\u91cd\u6e1b\u5c11\u3001\u4f53\u8102\u80aa\u7387\u3068\u8840\u6f3f\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\u306e\u4f4e\u4e0b\u3001\u7a7a\u8179\u6642\u9ad8\u8840\u7cd6\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u8010\u6027\u969c\u5bb3\u3001\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u5909\u5316\u3001\u7d30\u83cc\u6027\u77ed\u9396\u8102\u80aa\u9178\u3067\u3042\u308b\u30d7\u30ed\u30d4\u30aa\u30f3\u9178\u5869\u306e\u8840\u6e05\u6fc3\u5ea6\u4e0a\u6607\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u7d50\u679c\u304b\u3089\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306f\u9ad8\u8102\u80aa\u98df\u306b\u3088\u308b\u5f71\u97ff\u306e\u591a\u304f\u3092\u7de9\u548c\u3057\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u9ad8\u8840\u7cd6\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u8010\u6027\u969c\u5bb3\u3092\u3082\u305f\u3089\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306e\u8a66\u9a13\u8a08\u753b\u306b\u8ab2\u984c\u304c\u5728\u308b\u3053\u3068\u3001\u591a\u304f\u306e\u5b66\u8853\u7684\u77e5\u898b\u3068\u77db\u76fe\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u306e\u9577\u671f\u9593\u7d99\u7d9a\u3068\u4ee3\u8b1d\u3084\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u306e\u5909\u5316\u306b\u95a2\u4fc2\u304c\u3042\u308b\u3068\u306e\u6839\u62e0\u306b\u306f\u306a\u308a\u5f97\u307e\u305b\u3093<\/p>\n<div class=\"su-accordion su-u-trim\">\n<div class=\"su-spoiler su-spoiler-style-default su-spoiler-icon-plus su-spoiler-closed\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-spoiler-title\" tabindex=\"0\" role=\"button\"><span class=\"su-spoiler-icon\"><\/span><strong>\u5f15\u7528\u6587\u732e<\/strong><\/div><div class=\"su-spoiler-content su-u-clearfix su-u-trim\">\n<p>Bell DSH. <strong>Changes seen in gut bacteria content and distribution with obesity: causation or association? <\/strong><em>Postgrad Med<\/em>.2015;127(8):863-868<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26474235\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26474235<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>European Food Safety Authority. <strong>Scientific Opinion on the re-evaluation of aspartame (E951) for the proposed uses as a food additive. <\/strong><em>EFSA J.<\/em> 2013;11(12):3496.<\/p>\n<p><u><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.2903\/j.efsa.2013.3496\/epdf\">http:\/\/onlinelibrary.wiley.com\/doi\/10.2903\/j.efsa.2013.3496\/epdf<\/a><\/u><\/p>\n<p>&nbsp;<\/p>\n<p>Higgins KA, et al. <strong>Aspartame Consumption for 12 Weeks Does Not Affect Glycemia, Appetite, or Body Weight of Healthy, Lean Adults in a Randomized Controlled Trial.<\/strong> <em>J Nutr<\/em>.2018;148(4):650\u2013657.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29659969\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29659969<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Jumpertz R, et al. <strong>Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans<\/strong>. <em>Am J Clin Nutr<\/em>.2011;94(1):58-65<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21543530\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21543530<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Kotzampassi K et al. <strong>Bacteria and Obesity: The Proportion Makes the Difference<\/strong>.<\/p>\n<p><em>Surgery Curr Res<\/em>.2013;3(5):1000152<\/p>\n<p><a href=\"https:\/\/www.omicsonline.org\/bacteria-and-obesity-the-proportion-2161-1076-3-152.pdf\">https:\/\/www.omicsonline.org\/bacteria-and-obesity-the-proportion-2161-1076-3-152.pdf<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Leon AS, Hunninghake DB, Bell C, Rassin DK, Tephly TR. <strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2802896\">Safety of long-term large doses of aspartame.<\/a><\/strong><em>Arch Intern Med<\/em>.1989;149(10):2318-24.<\/p>\n<p><u>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2802896<\/u><\/p>\n<p>Magnuson BA, et. al. <strong>Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies<\/strong>. <em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17828671\">Crit Rev Toxicol.<\/a><\/em><strong>2007<\/strong>;37(8):629-727<\/p>\n<p><u><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17828671\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17828671<\/a><\/u><\/p>\n<p>Nehrling JK et al. <strong>Aspartame use by persons with diabetes. <\/strong><em>Diab Care<\/em>.1985 Sep-Oct;8(5):415-7.<\/p>\n<p><u><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3902420\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3902420<\/a><\/u><\/p>\n<p>&nbsp;<\/p>\n<p>Palmn\u00e4s MS, et al. <strong>Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat<\/strong>. M\u00fcller M, ed. <em>PLoS ONE<\/em>.2014;9(10):e109841<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25313461\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25313461<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Schnorr SL, et al. <strong>Gut microbiome of the Hadza hunter-gathers<\/strong>. <em>Nat Commun<\/em>.2014;5:3654<\/p>\n<p><a href=\"http:\/\/www.nature.com\/articles\/ncomms4654\">http:\/\/www.nature.com\/articles\/ncomms4654<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Shanahan F, Murphy E. <strong>The hybrid science of diet, microbes, and metabolic health<\/strong>. <em>Am J Clin Nutr<\/em>.2011;94:1-2<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21633075\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21633075<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Suez J, et al.<strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25231862\"> Artificial sweeteners induce glucose intolerance by altering the gutmicrobiota<\/a><\/strong> <em>Nature<\/em>.2014;514(7521):181-186<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25231862\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25231862<\/a><\/p>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>By the Calorie Control Council \u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u3068\u6d88\u5316\u5668\u7cfb\u75c7\u72b6\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u306e\u6b86\u3069\u306e\u7591\u554f\u306f\u3001\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u6442\u53d6\u5f8c\u306e\u6d88\u5316\u5668\u7cfb\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3067\u89e3\u660e\u3067\u304d\u307e\u3059\u3002\u30ad\u30fc\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u79c1\u305f\u3061\u304c\u6bce &#8230; <a class=\"more-link\" href=\"https:\/\/global.aspartame.org\/ja\/gastrointestinal-issues-gut-microbiome\/\">Continue reading<\/a><\/p>\n","protected":false},"author":4,"featured_media":7095,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[181,1],"tags":[],"class_list":["post-6942","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-myths-ja","category-1"],"_links":{"self":[{"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/posts\/6942\/"}],"collection":[{"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/posts\/"}],"about":[{"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/types\/post\/"}],"author":[{"embeddable":true,"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/users\/4\/"}],"replies":[{"embeddable":true,"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/comments\/?post=6942"}],"version-history":[{"count":0,"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/posts\/6942\/revisions\/"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/media\/7095\/"}],"wp:attachment":[{"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/media\/?parent=6942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/categories\/?post=6942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/global.aspartame.org\/ja\/wp-json\/wp\/v2\/tags\/?post=6942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}